5-HTP (150mg)
is a direct precursor to serotonin, the neurotransmitter that regulates mood, sleep, and appetite. After partying, particularly with substances like MDMA, serotonin levels can be depleted, leading to the infamous “comedown.” Supplementing with 5-HTP helps replenish serotonin, which can significantly improve mood, reduce anxiety, and ease the post-party blues.
L-Tyrosine (250mg)
is a precursor to dopamine and norepinephrine, neurotransmitters crucial for mood, motivation, and mental sharpness. After partying, especially with stimulants, these neurotransmitters can become depleted, causing cognitive difficulties and apathy. L-Tyrosine helps restore these neurotransmitters, particularly beneficial in sleep-deprived states. It improves cognitive performance and combats comedown-related symptoms.
ALCAR (Acetyl L-Carnitine) (170mg)
has neuroprotective properties. Animal studies show that ALCAR protects serotonin-levels from drugs like MDMA and ketamine. ALCAR improves cellular energy production and aids in brain health by indirectly increasing choline levels and increasing receptors for nerve growth factors. These effects support overall brain health and improve cognitive function.
NAC (N-Acetyl Cysteine) (100mg)
is a powerful antioxidant that helps replenish glutathione, the body's master antioxidant, which protects the liver and aids in detox (it even helps remove heavy metals from the body). NAC may reduce cravings and support recovery by modulating brain neurotransmission, particularly dopamine and glutamate (virtually all recreational substances except heroin target the glutamate system).
Alpha-GPC (150mg)
increases dopamine levels and is involved in acetylcholine production, a neurotransmitter linked to memory, focus, and cognitive function. By supporting dopamine function and acetylcholine production, it may help regulate mood and mitigate concentration difficulties often experienced during comedowns.
ALA (R-alpha-Lipoic Acid) (44 mg)
is a potent antioxidant with neuroprotective attributes that can cross the blood-brain barrier and support mitochondrial function. In a study on rats, ALA was found to fully prevent MDMA-induced serotonergic deficits.
Black Pepper Extract (20 mg)
has been proven to enhance the bioavailability of several nutrients and compounds.
This extract stimulates the production and release of intrinsic factor, which is crucial for the absorption of Vitamin B12. By inhibiting certain enzymes in the digestive system, the piperine in black pepper extract slows the breakdown of 5-HTP, allowing more of it to reach the brain. For NAC, the extract amplifies its therapeutic benefits, particularly in liver protection. Black pepper extract also enhances the bioavailability of vitamins B6 and C, iron, calcium, Acetyl-L-Carnitine, and R-alpha-Lipoic Acid.
Myo-Inositol (50 mg)
is involved in neurotransmitter signaling and may help regulate mood and anxiety.
Comprehensive Multivitamin
Vitamin A (249µg) aids in maintaining vision and skin health, supporting overall recovery.
Vitamin B1 (Thiamin, 0.3mg) is essential for glucose metabolism and neurotransmitter synthesis, including acetylcholine, serotonin, and amino acids like aspartate and glutamate. It supports serotonin uptake and the activity of brain regions involved in mood regulation and cognitive functions.
Vitamin B2 (Riboflavin, 0.5mg) acts as an antioxidant supporting nervous system health.
Vitamin B3 (Niacin, 2.8mg) improves brain function, potentially reducing brain fog, and may have antidepressant effects by influencing the kynurenine pathway.
Vitamin B6 (0.5mg) supports the synthesis and regulation of neurotransmitters like serotonin, dopamine, and GABA (the GABA system is directly targeted by alcohol, benzodiazepines, barbiturates and GHB/GBL and by indirectly by cocaine and nicotine).
Vitamin B9 (Folate, 58µg) supports red blood cell production and may mitigate genomic damage from drug use.
Vitamin B12 (0.7µg) has neuroprotective properties, potentially attenuating neuronal degeneration and decreasing neurotoxicity induced by substances like methamphetamine. It's particularly crucial for those using nitrous oxide.
Vitamin C (11mg) combats increased oxidative stress from substance use and sleep deprivation and aids the immune system.
Vitamin D (5.2µg) plays a role in sleep regulation and a balanced mood, especially when sleep deprived.
Vitamin E (2.8mg) protects cells from oxidative damage and has anti-inflammatory properties.
Essential Mineral Blend
Calcium (204 mg) is essential for muscle and nerve function as it may help reduce post-party muscle cramps and support neurotransmitter release, aiding in mood regulation during comedowns.
Magnesium Glycinate (482mg) is an essential mineral crucial for muscle and nerve function, energy production, and neurotransmitter regulation. In the context of partying and substance use, it may reduce muscle tension, cramping, and jaw clenching - common stimulant side effects. Magnesium supports GABA production, promoting relaxation and counteracting comedown-related overstimulation and anxiety. It can improve sleep quality disrupted by partying and mitigate fatigue and mood disturbances.
Potassium (258 mg) is an essential electrolyte that helps maintain proper fluid balance, nerve signaling, and muscle function. After partying, especially with alcohol consumption or excessive sweating, potassium levels can become depleted. Replenishing potassium may help reduce fatigue, muscle cramps, and support overall recovery.
Trace Minerals
Chromium (20 µg) plays a crucial role in glucose metabolism and enhances cellular insulin activity, promoting the entry of tryptophan into the brain, a precursor for serotonin. Chromium also influences dopamine pathways through its interaction with the serotonergic system. By improving insulin sensitivity, it may help stabilize energy levels and reduce cravings.
Iodine (43 µg) is crucial for thyroid function, cognitive function and detoxification of harmful compounds like halides and heavy metal.
Manganese (1 mg) helps protect cells from oxidative stress and plays a role in dopamine synthesis and regulation. Manganese also supports overall metabolism and detoxification processes.
Molybdenum (27.5 µg) is a trace mineral that mainly works as a cofactor for enzymes. It helps with neurotransmitter balance by supporting the synthesis of dopamine and serotonin through the metabolism of sulfur-containing amino acids. It also aids in the liver's detoxification processes by enabling enzymes that break down toxins, such as the alcohol metabolite acetaldehyde.
Zinc Picolinate (33mg) plays a crucial role in immune function, protein synthesis, and wound healing. It also supports neurotransmitter function and may help regulate mood. After partying, zinc supplementation could potentially aid in immune system recovery and support overall well-being.
